Monday, April 25, 2011

Published Study Validates New Protein Enrichment Approach For Low-Abundance Biomarker Detection

Hercules, CA — April 20, 2011 — University of Minnesota researchers found that Bio-Rad Laboratories' ProteoMiner protein enrichment kit enhanced identification of changes to low-abundance proteins and detection of post-translationally modified (PTM) proteins in human saliva. These findings offer promise for improving differential proteomic analyses and biomarker studies aimed at identifying disease-specific proteins and their PTM variants in various types of biological samples and fluids. The study was published in the Dec. 13, 2010, issue of the Journal of Proteome Research.
ven when highly sensitive mass spectrometers are used to analyze complex biological samples and bodily fluids, high-abundance proteins obscure the detection of lower-abundance proteins and their post-translational modifications," said Sri Bandhakavi, who led the study at the University of Minnesota in 2010. (Bandhakavi is now a senior scientist at Bio-Rad.) "These lower-abundance proteins and PTMs are often of most interest to researchers, given their association with specific disease or physiological states."

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