MSE from Waters - the ultimate technology for reproducible profiling

"Waters mass spectrometers provide a method of data acquisition - known as MS^E - that records exact mass precursor and fragment ion information from every detectable component in a sample. This method rapidly alternates between two functions: the first acquiring low-energy exact mass precursor ion spectra, the second acquiring elevated-energy exact mass fragment ion spectra. Every mass is measured, and spectra for each component aligned in retention time. This patented method records data without discrimination or pre-selection so your samples are completely catalogued in a single analysis.



When compared to Data Directed Analysis (DDA), MS^E maximizes instrument duty cycle by ensuring that exact mass precursor and fragment ion information data are obtained for the entire peak complement of a chromatogram, making it ideal for fast analysis and narrow, rapidly eluting peaks. DDA results in both a loss of data in the MS mode when MS/MS data are being acquired, and poor duty cycle. MS^E data is collected fast enough to accurately define the LC peaks for every detectable component.



MS^E is faster than traditional MS followed by MS/MS analysis, and provides data that is not readily obtained by DDA, as both MS and MS/MS data for all detectable components in the chromatogram are generated. MS^E can generate both precursor and product ions in a single analytical run thereby eliminating the need to rerun the samples to obtain further MS/MS spectra. To see MS^E in action and hear what scientists have to say about it, visit www.waters.com/MS^E."